Nano-Bio Interfaces

The Park group is also developing new nanoscale tools for interrogating living cells and cell networks. We pioneered the use of nanoneedles as a tool to deliver diverse biological effectors into living cells and have been applying it to interrogate intracellular circuits that dictate the functions of primary immune cells. Using the same nanoneedles, we also developed a highly scalable CMOS-based platform for recording and stimulating real-time dynamics of complex neuronal ensembles, and we are now actively using the tool to study the inner workings of the brain. In addition, we developed a pipeline for single-cell transcriptomics that is applicable to a broad range of cell types, and have used it to study the cell-to-cell variability of immune, cancer, and neuron cells.